منابع مشابه
Molecular Pathways: Fatty Acid Synthase.
Therapies that target tumor metabolism represent a new horizon in anticancer therapies. In particular, cancer cells are dependent on the generation of lipids, which are essential for cell membrane synthesis, modification of proteins, and localization of many oncogenic signal transduction enzymes. Because fatty acids are the building blocks of these important lipids, fatty acid synthase (FASN) e...
متن کاملFIRE (fatty acid synthase insulin-responsive element) and ICE (inverted CCAAT element) regulate fatty acid synthase.
Introduction Fatty acid synthase (FAS) plays a central role in de novo lipogenesis in mammals and birds by catalysing the reaction in the conversion of acetyl-CoA and malonyl-CoA into palmitate. FAS activity is not known to be regulated by allosteric effectors or covalent modifications. However, FAS concentration is exquisitely sensitive to nutritional, hormonal and developmental states [ 1-31....
متن کاملFatty Acid Synthase Impacts the Pathobiology of Candida parapsilosis In Vitro and during Mammalian Infection
Cytosolic fungal fatty acid synthase is composed of two subunits alpha and beta, which are encoded by Fas1 and Fas2 genes. In this study, the Fas2 genes of the human pathogen Candida parapsilosis were deleted using a modified SAT1 flipper technique. CpFas2 was essential in media lacking exogenous fatty acids and the growth of Fas2 disruptants (Fas2 KO) was regulated by the supplementation of di...
متن کاملMammalian fatty acid synthase: a chimeric protein which has evolved by gene fusion.
The pathway of fatty acid synthesis is carried out by all organisms that have been examined except the archaebacteria, which do not contain fatty acids in their membrane lipids (Fulco, 1983). The first seven reactions of the fatty acid synthesis pathway are identical in all eubacteria and eukaryotes. The only exception to this conservation of the reaction pathway is in the final chain terminati...
متن کاملMolecular Pathways Molecular Pathways: Fatty Acid Synthase
Therapies that target tumor metabolism represent a new horizon in anticancer therapies. In particular, cancer cells are dependent on the generation of lipids, which are essential for cell membrane synthesis, modification of proteins, and localization of many oncogenic signal transduction enzymes. Because fatty acids are the building blocks of these important lipids, fatty acid synthase (FASN) e...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2003
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(03)00029-2